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Maison is a six panel, spacious, responsive, magazine style WordPress theme suitable for any business. It has clean and elegant design with lots of features such as mega menu, featured section, widgetized sidebar, spiffy icons, and theme options to make the most out of your web presence.Spontaneous secretion of serotonin from rabbit atria.
The spontaneous secretion of serotonin was found to occur from isolated segments of rabbit atria under conditions in which it was previously undetectable. This release was confirmed in experiments employing high performance liquid chromatography with electrochemical detection. The serotonin release was found to have the characteristics of a Ca(2+)-dependent exocytotic event, with a slow onset and an overshoot before declining to a stable plateau level. A transitory elevation of calcium ion concentration was detected in the bathing medium, which is likely to be responsible for the observed elevated baseline secretion. Furthermore, the finding of a sufficient amount of endogenous serotonin suggests that an alteration of its metabolism may lead to alteration of local transmembrane ion gradients.The dual role of Rho GTPase Cdc42 in T-cell receptor signaling.
Accumulating evidence suggests that the Rho family of small guanosine triphosphatases (GTPases), originally discovered in studies of the morphology of motile organisms, is required for activation of many cell-surface receptors. This paper presents new evidence for a dual role of Cdc42, the prototypical member of the Rho family, in T-cell receptor (TCR) signaling. Induction of T-cell proliferation in response to antigen is blocked by Cdc42 RNAi-induced gene silencing and by a Cdc42-specific inhibitor. In the same cells, TCR-induced activation of tyrosine kinases and C-Jun N-terminal kinase (JNK), a substrate of JNK, was inhibited. The involvement of Cdc42 in TCR signaling is supported by two pieces of evidence. First, C