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Inhibition of αvβ6 integrin has been demonstrated to be of therapeutic benefit for several diseases including proliferative diseases of the breast and colon, osteoporosis and angiogenesis-dependent diseases. To further expand the chemical diversity of αvβ6 integrin antagonists, we developed a structure-guided approach focused on the C-8 amide/carboxylic acid region. From a comprehensive series of lead compounds, the C8-amides 16a-h and C8-carboxylic acids 15a-h were identified as potent ligands (in the low micromolar range), which inhibit VEGF-induced proliferation of bovine aortic endothelial cells (BAECs) with IC50 values of approximately 2-4 μM. The potencies of these derivatives are similar to the published reference compound Sunitinib. Among these C8-amides, compound 16g (CHEMBL164815) is noteworthy as it showed highest potency and selectivity in BAECs.Q:

Cannot run 3-node Cassandra with replication factor 2 in Kubernetes?

I am trying to run a Cassandra in Kubernetes with 3 nodes:

One static IP.
One Cassandra Node in the cluster (on Node 1, port 9042).
The other Node as data node in the cluster (on Node 2). (Note that I am not running this in the same pod as the Cassandra node).

If I run without replication factor 2 it works fine:
kubectl apply -f deploy/cassandra-config.yaml
replication-factor 2

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At mid-year, Mike Reeves, Head of International at Google, spoke at the Chicago Health Summit about the urgent need for medical professionals to take a more data-driven approach.

“The future of medicine is going to be much more data-driven, we think,” said Reeves, a doctor who trained and worked as a general surgeon before he joined the company in 2013 as director of life sciences and health. “You can be a doctor, but really it’s a software developer that knows the details of healthcare.”

Reeves also spoke of the growing proportion of people in the Western world that can access information through apps. Fifty-eight percent of people in the UK are accessing healthcare information through apps. “This is huge,” he said. “It’s important that we have good apps that make good sense.”

The inevitable conclusion from this is that doctors need to start making more use of data, but according to Reeves it won’t necessarily be straightforward. “If you think about general surgery
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