Pulmonary Physiology Lange Physiology By Michael G Levitzky
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The presence of 4′-amino groups in the 3′,4′-cyclic nucleotides (CN) 3′,4′-cyclic ADP-ribose (cADPR) and its 4′-O-substituted analog, 2’O-(2,3:4,5-di-O-Me-cyclohexylidene-beta-D-galactopyranosyl)-3′,4′-cyclic AMP (2′), was found to be essential for their inhibitory effects on mitochondrial oxidative phosphorylation in rat liver homogenates. The 2′,3′-di-O-substituted analog, 2′,3′-O-(2,3:4,5-di-O-Me-cyclohexylidene-beta-D-galactopyranosyl)-3′,4′-cyclic AMP (3′), which is present in equimolar amounts to 2’O-(2,3:4,5-di-O-Me-cyclohexylidene-beta-D-galactopyranosyl)-3′,4′-cyclic AMP (2′), has a higher inhibitory potency than 2’O-(2,3:4,5-di-O-Me-cyclohexylidene-beta-D-galactopyranosyl)-3′,4′-cyclic AMP (2′) and 2′,
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