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Bacteria inside a person’s gut can communicate, revealing how patients can use that information to recover and fight off infections—a finding that could lead to a new class of antibiotics.

The new study shows that the gut’s resident microbiota can detect an infection by a bacterial species that normally resides in the throat, much like how a mouse can sense the presence of mouse-borne parasites by monitoring the air for their breath.

“Bacteria living in the gut distinguish between the bacteria that live in your gut and the bacteria that live outside your gut,” says David B. Relman, the J.C. Newman Professor of Microbiology at the University of California, Berkeley, and senior author on the study, which appears in the October issue of the journal Science.

“That is extremely useful, because if you have an infection in your gut, you can also fight off an infection in your gut,” Relman says.

Michael Fischbach, a professor at the University of Pennsylvania and corresponding author of the study, says, “I think this study reveals a new paradigm in microbial ecology.”

Usually, most bacteria are not actively involved in the health of a patient, he says. “With respect to the gut, you never know when a disease is going to strike, but when it does you have much better success at dealing with it if you’ve got some resident microbiota on hand.”

Relman and Fischbach developed a technique that allows researchers to identify bacteria that communicate with one another in a controlled environment. They selected three different species of bacteria—two from the human body and one from a common house fly—and gave them different sets of foods to eat for two weeks, each of which supported a different set of microorganisms.

When the scientists fed one of the bacteria a substance commonly found in infected people—lipopolysaccharide—that bacterial species began to produce a chemical that signaled its fellow gut bacteria to respond. The scientists also fed the same bacteria a substance typically found in the mouth—glucose—that triggered a different, less specific response.

“It was like a game of ‘telephone,’

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